Congenital disorders contribute significantly to child mortality and long-term disabilities, especially in low- and middle-income countries. Save the Children is taking action by integrating neonatal screening into healthcare systems, ensuring early detection and intervention to improve health outcomes. Save the Children’s initiatives in Uganda and Albania highlight the importance of strengthening healthcare protocols and infrastructure, supporting families, and advocating for increased global investment in newborn health. By scaling up early detection programs, policymakers and stakeholders can help mitigate the impact of congenital disorders and safeguard children’s futures.